Clinical evaluation of AV DERMACARE CREAM in cases of eczema and dermatitis
Bio-assay directed investigations by researchers at the Department of Medicinal Chemistry, Kansas University showed reproducible antimicrobial activity in vitro against Staphylococus aureus, Mycobacterium smegmalis and Candida albicans. Researchers at the Institute of Microbiology II, University of Cagliri, Italy reported the antiviral activity of Glycyrrhizic acid. The authors reported that the drug inhibits growth and cytopathology of several unrelated DNA and RNA viruses, while not affecting cell activity and ability to replicate. In addition they also reported that the drug inactivates herpes simplex virus particles irreversibly
The seeds of Psoralea corylifolia have been used as an ancient Hindu remedy for leucoderma and vitiligo. The furanocoumarin psoralen has been shown to be active against T cell lymphoma. In the review by Siddiqui and Ansari, Psoralea corylifolia was reported to have a marked action on undifferentiated protoplasm such as paramecium. In 1 in 50,000 dilutions of the oil, the paramecia remain alive and active fro 15 minutes after 25 minutes the movements are slowed and death is observed in 40-45 minutes. In 1 in 10,000 dilution death was reported in 10 minutes. The oil of the seeds was reported to exhibit antibacterial activity against gram positive and gram negative human pathogenic bacteria. The oil also showed anti-fungal activity against Asparagillus niger, A. candidus, Microsporum gypsum and Rhizopus nigricans. Rangari & Agarwal in their review have reported that the plant has antileucodermal activity. It was reported that after a few days of application pigmentation was noticed and the development of fresh patches was arrested. The authors reported that trials at the Calcutta School of Tropical Medicine showed that the extracts of P. corylifolia were effective in cases of Leucoderma.
Kakkar in his report on Centella asiatica has noted that Mandukparni has been used as an antileprotic drug for centuries. The first clinical study was conducted in 1904 at the Madras Leper Hospital. In 1942 Botemps isolated an active principle namely “ Asiaticoside”. Since that time many scientists have studied the action of this herb in treatment of skin diseases. Ratsimamanga in 1963 isolated Asiatic acid and this compound was shown to have bactericidal properties. The Martindale Extra Pharmacopoeia lists Centella asiatica as a dermatological agent Titrated Extract from Centella asiatica (TECA) is a drug which has been used for many years in Europe for the treatment of wound healing defects. It is a reconstituted mixture of 3 triterpenes extracted from the plant, asiatic acid, madecassic acid and asiaticoside. In this report, we studied the effects of TECA and its separated components in the wound chamber model described by Schilling et al. Stainless steel wound chambers were surgically inserted under the skin of rats and received serial injections of either TECA or its purified components. Chambers were collected at days 7, 14, 21 or 28 for biochemical analysis or histological examination. TECA-injected wound chambers were characterized by increased dry weight, DNA, total protein, collagen and uronic acid contents. Peptidic hydroproline was also increased, showing an increased remodeling of the collagen matrix in the wound. The 3 purified components of TECA were all able to reproduce the effects of the complete drug, with some differences depending on the product. Asiatic acid and asiaticoside were the most active of the 3 triterpenes. Asiaticoside exerted a preferential stimulation of collagen synthesis and was active at low doses only. In addition to collagen, the 3 components were also able to stimulate glycosaminoglycan synthesis
Effect of Azadirachta indica extracts on inflammatory oedema induced by chemical mediators ( 5-HT, Histamine, bradykinin, and PGE) was demonstrated in a study by Chattopahdy et al. The test material showed significant anti-inflammatory effect against 5-HT and PGe1 induced inflammation. The extracts of Azadirachta indica have been used in various topical applications due to its proven activity against inflammation as well as fungal infections.
The extracts of Pongamia glabra were tested against Trichopyton verrucosum, Trichopyhton mentagrophytes and Trichopyton simii by cup plate method. The extract showed a zone of inhibition greater than 100 mm in radius. The test showed that the extracts of Pongamia glabra demonstrated considerable anti-fungal activity making it useful in ythe treatment of skin disease.