Clinical Evaluation of Mormodica chanrantia extract in diabetes
The leaves of Gymnema sylvestris lower blood sugar, stimulate heart and raise urine output . The hypoglycemic activity of leaf powder have been reported both in rabbits and men . Also, leaves of Gymnema syvestris given to diabetics reduce urine sugar level . The hypoglycemic extract of Gymnema sylvestris R.Br. brings about blood glucose homeostasis, which in turn prevents increased glycosylation of proteins thus reversing the onset of changes leading to micro and macroangiopathy. Control of Diabetes mellitus and the associated complications are mediated through the revival or regeneration of the insulin, producing beta -cells in the islets of langerhans .
The fruit juice has anti-diabetic activity . Extracts of seed of Eugenia jambolana alleviate glycosuria and Hypoglycemia .
Pterocarpus marsupium is an anti-diabetic drug . It have been proved to be effective in diabetes by releasing insulin , by regenerating beta cells of islets of langerhans of pancreas .
Trigonella foenum-graecum seeds have been shown to possess hypoglycemic properties in both animal and human subjects . The soluble dietary fiber (SDF) when fed simultaneously with glucose showed significant hypoglycemic effect in rats. However, compounds other then SDF is/are also involved in the hypoglycemic activity .
It has been reported that the aqueous extract of tender leaves of Azadirachta indica tree reduced blood sugar in dogs . Also, its oil, leaf decoction and nimbidin significantly delayed the peak rise in blood sugar after glucose administration. Further, it was found that glucose tolerance test curves are similar to that of Tolbutamide .
The plant is bitter with a sharp taste, astringent, tonic, stomachic, lessens inflammation . The extract exhibits hypoglycemic activity .
Shilajit is employed in diabetes in which it reduces the quantity of sugar and urine .
The leaves and bark have been claimed to be effective in the management of diabetes . Oral administration of 50% ethanolic extract of C. tamala leaves significantly lowered the plasma glucose levels in normoglycaemic and streptozotocin hyperglycaemic rats. The extract also exhibited anti hypercholestrimic and antihypertriglyceridemic effects in streptozotocin-hyperglycaemic rats
Tinospora cardifolia has been proved to be a hypoglycaemic agent .Plant extract caused reduction in fasting blood sugar in rabbits and rats .
The ethanolic extract of Piper longum exerted hypoglycaemic effect in rats and also counteracted the spasms induced by various spasmogens in isolated guinea pig ileum.