Celastris has been traditionally used in products that enhance memory. Researchers in India found that the proprietory extract of C. paniculata possesses tranquilizing, sedative, central muscle relaxant, anti-inflammatory, anti-pyretic, anti-ulcerogenic, anti-emetic, analgesic and adaptogenic properties Other researchers reported the seed Oil extract of C.paniculatus obtained from Amsar Private Limited, to have memory enhancing effect besides anti-anxiety and lipid lowering properties in albino rats of either sex. Celastrus paniculata decreased transfer latency in elevated plus maze in the rats receiving 60 mg/kg and decreased the secondary avoidance blockade in conditioned avoidance response.
Nir Brahmi ( Bacopa monniera Linn.) is a reputed nervine tonic in Ayurvedic literature. It has been the focus of a 30 year study to establish the scientific basis of it's action. Scientists of the Indian laboratory at the Central Drug & Research institute (CDRI) have isolated and characterized the two major compounds: Baccoside A & Baccoside B. The extract contained in this product is the same extract developed by this premier institute and contains 50% Baccosides A & B. This herb is reputed to be the one Lord Brahma used and therefore the name Brahmi is given to it. Researchers administered the aqueous suspension of the proprietory extract (40mg/kg,p.o.) for three or more days to rats. The first schedule induced a labile behavior using a shock motivated brightness discrimination reaction. The brahmi-treated group showed a better acquisition, improved retention and delayed extinction (p< 0.01-0.05). similarly, in an active conditioned flight reaction, the drug-treated animals showed a shorter reaction time than the controls(p<0.01) . Also in the continuous avoidance response the drug-treated group performed better than the controls (p<0.01 - 0.05). B. monneri L. has been widely used in the treatment of mental retardation, epilepsy and insanity in the traditional system of Indian medicine
Withania somnifera is used in Ayurvedic medicine as a medhrasayan, which promotes learning acquisition and memory retrieval. Withania somnifera is one of natures wonders as it has proven to be useful in a host of diseases. It's use in cancer has been investigated, it's anti-anxiety activity has been proven. It is very useful in cases of memory loss, anxiety, fatigue. Scientists have studied the effect of Withania somnifera on Dopaminergic receptors in Rat Brain during stress. The animals were subjected to immobilization stress for 5 hrs., and the dopamine receptor population of the corpus striatum was studied by [3H] spiroperidol ligand binding without and after pretreatment with the proprietory extracts of withania somnifera. The results showed that the DA receptor population was significantly increased after stress which was prevented by pretreatment with Withania somnifera. Other researchers investigated the neuropharmacological activity of Withania somnifera and reported that the proprietory extract potentiates the pentabarbitone induced hypnosis. They observed that there was a significant increase in the pentylenetetrazole induced seizure latency in 8 days treatment.
Trikatu is a group of three acids i.e. Piper nigrum, Piper longum, Zingiber officinalis. Trikatu increases drug bioavailability either by promoting rapid absorption from the gastrointestinal tract or by protecting the drug from being metabolized/oxidized in its first stage through the liver after being absorbed, or by the combinations of these mechanisms
Argarwal & Singh, have reported that the proprietory extracts prolonged the hypnotic effect of sodium phenobarbitone in mice and rats. It reduced the amphetamine toxicity by 20 to 30 per cent in mice. No protection was seen against convulsions produced either by metrazol in mice or by electric shock seizures in rats. Significant fall in rectal temperatures of rats which was maximum at two hours, was shown with a dose of 100mg/kg. The proprietory extract and the glycosides have shown mild tranquilizing effect The whole plant and the leaves of C. asiatica are taken as tonic and for the improvement in memory. The extracts and powders have shown to have significant activity in improving mental ability in mentally retarded children. A six week treatment in patients with anxiety neurosis reduced anxiety levels and showed improvement in the mental fatigue rate and immediate memory span. It has been found efficient in the treatment of educable mentally retarded children of age range 8-12 years and improved general mental ability of mentally retarded children.
The proprietory extract of the roots of t. cordifolia was investigated for its effect on brain amine levels in stressed rats. It was found to possess normalizing activity against stress induced changes in norepinepherine (NE), dopamine (DA), 5-hydroxytryptamine (5-HT) and 5-hydroxtindole acetic acid (5-HIA) levels (20).
Dr . H. K. Kushwaha and Dr K.P. Sharma conducted an indepth study on Shankpushpi in the management of Depressive illness. The Researchers felt that Depression is a major disorder leading to various social problems. They therefore undertook a study specifically to investigate the role of this traditional herb in depressive illness.
20 Patients were chosen suffering from depression. 15 males and 5 females were the subject of the study. All patients were screened to ensure that the illness exhibited was chronic and not the result of an immediate emotional issue. The chosen patients exhibited mild to moderate symptoms of depressive disorders.
The antidepressant activity was noted to be significant with 20% of the treated group showed a moderate improvement, 60 % showed a positively marked improvement and 20% showed excellent improvement. Correspondingly 60 % of the group
on placebo did not show any change whilst 40% showed moderate improvement. The Researchers concluded that Shankpushpi has an important role to play in the management of depressive disorders.